Nogo to synapse formation

Nogo and Nogo receptor: relevance to schizophrenia?

The membrane protein Nogo-A and its receptor NgR have been extensively characterized for their role in restricting axonal growth, regeneration, and plasticity in the central nervous system. Recent evidence suggests that Nogo and NgR might constitute candidate genes for schizophrenia susceptibility. In this article, we critically review the possibility that dysfunctions related to Nogo-A and NgR...

NRP1 and synapse formation

Perception and behavior are critically dependent on synaptic communication between specific neuronal types. Understanding how neurons achieve such a “synaptic specificity” is therefore one of the most fundamental issues in developmental neuroscience. The final lock between the preand post-synaptic elements is the culmination of a multiple-step program that includes cell migration, cell differen...

Synapse formation in retinoblastoma tumours.

Developing photoreceptor-like cells in retinoblastoma tumour fleurettes were found to contain apical tight junctions, mitochondrial-filled inner segment regions with cilia, and basally located synaptic ribbons and vesicles. Synaptic contract appeared to be established with adjacent neuronal-like elements. We suggest that photoreceptor differentiation in retinoblastoma tumours follows a sequence...

Synapse formation in retinoblastoma tumours

Cell adhesion and synapse formation

Although numerous molecules have been associated with synaptic cell adhesion, there has been little conclusive evidence linking them to specific effects on synapse formation and function. By searching vertebrate sequence databanks, a novel homophilic synaptic cell adhesion molecule called SynCAM has been found which is homologous to members of the immunoglobulin-like (Ig) superfamily and in vit...